Scientists have discovered a natural compound in flowers that blocks an enzyme linked to multiple sclerosis and cancer progression.
Why it matters: This breakthrough could lead to new treatments for MS and various cancers. The discovery also demonstrates how natural compounds are valuable sources for medical innovations.
- MS and cancer affect millions globally, with limited treatment options currently available.
Key finding: The compound sulfuretin, found in dahlia and coreopsis flowers, inhibits CEMIP, an enzyme that breaks down hyaluronic acid and contributes to disease progression.
“We think this is a drug that could have impact in a lot of different areas.”
Larry Sherman, Ph.D., professor at OHSU’s Oregon National Primate Research Center
The process:
- Undergraduate students spent years screening plant compounds
- Researchers tested sulfuretin in live cells
- The compound successfully blocked CEMIP activity in tumor cells and oligodendrocyte progenitor cells
Keep in mind: While promising, the research is still in early stages – animal trials are needed to confirm effectiveness and identify potential side effects.
Real-world impact: Beyond MS and cancer, this discovery could potentially help treat:
- Osteoarthritis
- Skin infections
- Brain injuries from alcohol use
- Alzheimer’s disease
- Premature infant brain development issues
TL;DR
- A natural compound found in flowers blocks an enzyme involved in MS and cancer progression.
- The discovery resulted from years of undergraduate research screening plant compounds.
- The finding could impact treatment for multiple conditions beyond MS and cancer, including Alzheimer’s and brain injuries.
Read the Paper
Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation